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Olivier Restif

Dynamic models for host-pathogen interactions

I use mathematical and statistical models to help with the design, analysis and interpretation of empirical studies of infectious disease dynamics. My research falls into two main areas:

1. Within-host dynamics of bacterial infections.

Laboratory animal models provide important data on the dynamics of bacterial infection inside a living organism, but observations are limited. Using mathematical models, my aim is to extract as much information as possible from experimental data to make inference about the unobserved processes that drive the spatiotemporal dynamics of bacteria. In particular, I try to assess variations in the replication and death rates of bacteria, and their spread within and among tissues.

My work covers several bacterial pathogens thanks to a fantastic network of collaborators:

- Salmonella enterica, with Andrew Grant and Piero Mastroeni (in this Department)

- Streptococcus pneumoniae, with Marco Oggioni (University of Leicester)

- Bordetella bronchiseptica, with Eric Harvill (Penn State University)

Funding: BBSRC, MRC.

 

2. Wildlife epidemiology.

The emergence of new viruses from bats in the last 30 years has drawn the attention of a broad scientific community to the ecology and immunology of this diverse group of mammals. We have established a successful international collaboration centred in Ghana to study African fruit bats, their ecology, their viruses and their interactions with people.

Collaborators:

- Andrew Cunningham (Institute of Zoology, ZSL)

- Raina Plowright (Montana State University)

- Hamish McCallum and Alison Peel (Griffith University)

 

Key Publications

 

 

Dr Olivier Restif

Alborada Lecturer in Epidemiology

or226@cam.ac.uk

    Plain English

    I develop mathematical models to simulate the dynamics of diseases, either within an infected animal or across populations. I collaborate with microbiologists who study bacterial infections in the laboratory, and with ecologists who track diseases in wildlife.

    Funding

    Royal Society (University Research Fellowship), BBSRC, MRC.

    Olivier is currently accepting applications for PhD students. Olivier is also available for consultancy.