Innate immune responses to bacterial infection
I am a molecular microbiologist with interests in bacterial metabolism and virulence, and the interaction of pathogenic bacteria with host cells and tissues and the innate immune system. My work is focused on applying novel physical and imaging techniques combined with molecular genetic approaches to study these processes.
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Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. S.M. Man, L.J. Hopkins, E. Nugent, S. Cox, I.M. Glück, P. Tourlomousis, J.A. Wright, P. Cicuta, T.P. Monie and C.E. Bryant. (2014). Proceedings of the National Academy of Sciences USA, 111, 7403-7408.
The lipoprotein components of the Isd and Hts transport systems are dispensable for heme acquisition by Staphylococcus aureus.J.A. Wright and S.P. Nair. (2012). FEMS Microbiology Letters, 329, 177-185.
Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to modulation of the intracellular environment via TLR4 signalling. J.A. Wright*, S.S. Tötemeyer*, I. Hautefort, C. Appia-Ayme M. Alston et al. (2009). Microbiology, 155, 2919-2929. *joint first authors.
Metabolite and transcriptome analysis of Campylobacter jejuni in vitro growth reveals a stationary phase physiological switch.J.A. Wright, A.J. Grant, D. Hurd, M. Harrison, E.J. Guccione, D.J. Kelly and D.J. Maskell. (2009) Microbiology. 155, 80-94