skip to primary navigationskip to content
 

John Wright

Innate immune responses to bacterial infection

I am a molecular microbiologist with interests in bacterial metabolism and virulence, and the interaction of pathogenic bacteria with host cells and tissues and the innate immune system. My work is focused on applying novel physical and imaging techniques combined with molecular genetic approaches to study these processes.

Stills of live fluorescence imaging of bacterial-cell contact dynamics. (a) Salmonella in contact with a macrophage (edge indicated by the white dotted circle, scale bar 5um). (b) Macrophages infected with Salmonella. Yellow arrows show bacteria taken up by macrophages. Green arrows show bacteria in contact with the macrophage surface (scale bar 25um).

Key Publications

Google Scholar - link to all publications
The frequency and duration of Salmonella-macrophage adhesion events determines infection efficiency. S. Achouri*, J.A. Wright*, L. Evans, C. Macleod, G. Fraser, P. Cicuta and C.E. Bryant. (2015). Philosophical Transactions of the Royal Society B, 370, 20140033. *joint first authors.
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. S.M. Man, L.J. Hopkins, E. Nugent, S. Cox, I.M. Glück, P. Tourlomousis, J.A. Wright, P. Cicuta, T.P. Monie and C.E. Bryant. (2014). Proceedings of the National Academy of Sciences USA, 111, 7403-7408.
The lipoprotein components of the Isd and Hts transport systems are dispensable for heme acquisition by Staphylococcus aureus.J.A. Wright and S.P. Nair. (2012).  FEMS Microbiology Letters, 329, 177-185.
Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to modulation of the intracellular environment via TLR4 signalling. J.A. Wright*, S.S. Tötemeyer*, I. Hautefort, C. Appia-Ayme M. Alston et al. (2009). Microbiology, 155, 2919-2929. *joint first authors.
Metabolite and transcriptome analysis of Campylobacter jejuni in vitro growth reveals a stationary phase physiological switch.J.A. Wright, A.J. Grant, D. Hurd, M. Harrison, E.J. Guccione, D.J. Kelly and D.J. Maskell. (2009)  Microbiology. 155, 80-94

 

 

Dr John Wright

Senior Research Associate

jaw55@cam.ac.uk

Group members: Professor Clare Bryant, Dr Panagiotis Tourlomousis, Dr Lee Hopkins, Dr Jessica Bergman, Dr Craig Hughes, Alessandra Bittante, Alessandro Rizzo, Milton Pereira, Charlotte Macleod

 

    Plain English

    I study how infectious bacteria grow and damage their host organism, and in turn how the host detects and responds to this infection. To do this I use genetic approaches to inactivate components in both the bacteria and the host to determine how important these components are, and use advanced microscopes to watch the interaction between the organisms in real time.