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Mark Holmes

Antimicrobial resistance, Molecular Epidemiology, Clinical Veterinary Research, Evidence-based Veterinary Medicine

My group's current focus of research follows our discovery of a new livestock-associated MRSA harboring a mecA homologue (now named mecC). The new MRSA was discovered during an epidemiological project looking at the transmission of S. aureus in dairy cows by one of our PhD students, Laura Garcia Alvarez. The original isolate was whole genome sequenced and analysed in collaboration with the Wellcome Trust Sanger Institute by Matt Holden and colleagues. We subsequently obtained funding from Defra and the MRC to investigate the discovery further. We are now undertaking studies to establish the prevalence and diversity of the new 

Milk sampling during our MRSA studiesMRSA using whole genome sequencing and other techniques. In collaboration with Prof Alexander Tomasz’s lab at Rockefeller University we have recently published the results of a study into the function of the PBP2a produced by the mecC gene.

Mark also has interests in clinical research (including animal welfare) and evidence-based veterinary medicine and has published a number of papers and books in these areas.

Main collaborators

  • Sharon Peacock, Dept of Medicine, University of Cambridge
  • Julian Parkhill & Matt Holden, Wellcome Trust Sanger Institute
  • Ruth Zadoks, Moredun Institute
  • Giles Edwards, Scottish MRSA reference laboratory
  • Robert Skov & Anders Rhod Larsen, Serum Statens Institut, Copenhagen
  • Angela Kearns & Bruno Pichon, Health Protection Agency
  • Alexander Tomasz, Rockefeller University
  • Herminia de Lencastre, ITQB/UNL
  • Frederic Laurent, University of Lyon
  • Wolfgang Witte & Christiane Cuny, Robert Koch-Institutes
  • Katleen Hermans, Ghent University
  • Birgit Walther & Torsten Semmler, Freie Universität Berlin
  • Sara Hæggman, Swedish Institute for Communicable Disease Control

Key Publications

Google Scholar - list of all publications

Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid. Ba X, Harrison EM, Lovering AL, Gleadall N, Zadoks R, Parkhill J, Peacock SJ, Holden MT, Paterson GK, Holmes MA. Antimicrob Agents Chemother. 2015 Dec;59(12):7396-404. Epub 2015 Sep 21.

Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015. Hadjirin NF, Lay EM, Paterson GK, Harrison EM, Peacock SJ, Parkhill J, Zadoks RN, Holmes MA. Euro Surveill. 2015 Jun 18;20(24). pii: 21156.

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission. Paterson GK, Harrison EM, Murray GG, Welch JJ, Warland JH, Holden MT, Morgan FJ, Ba X, Koop G, Harris SR, Maskell DJ, Peacock SJ, Herrtage ME, Parkhill J, Holmes MA. Nat Commun. 2015 Mar 27;6:6560. doi: 10.1038/ncomms7560.

A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals. Harrison EM, Weinert LA, Holden MT, Welch JJ, Wilson K, Morgan FJ, Harris SR, Loeffler A, Boag AK, Peacock SJ, Paterson GK, Waller AS, Parkhill J, Holmes MA.
MBio. 2014 May 13;5(3):e00985-13. doi: 

Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. García-Álvarez L, Holden MT, Lindsay H, Webb CR, Brown DF, Curran MD, Walpole E, Brooks K, Pickard DJ, Teale C, Parkhill J, Bentley SD, Edwards GF, Girvan EK, Kearns AM, Pichon B, Hill RL, Larsen AR, Skov RL, Peacock SJ, Maskell DJ, Holmes MA. Lancet Infect Dis. 2011 Aug;11(8):595-603.

 

Dr Mark Holmes

Reader in Microbial Genomics and Veterinary Science

mah1@cam.ac.uk

Group members: Dr Xiaoliang (Ibrahim) Ba, Dr Stefan De Vries,  Dr Srishti Gupta, Dr Michael Bateman, Ms Nazreen Hadjarin, Ms Claire Raisen

    Plain English

    The main theme of my current research is in looking at how resistance to antibiotics develops and is maintained in the bacteria that live in human and animal hosts.

    Location of original human and bovine mecC MRSA isolates