Dynamic models for host-pathogen interactions
I use mathematical and statistical models to help with the design, analysis and interpretation of empirical studies of infectious disease dynamics.
1. Within-host dynamics of bacterial infections.
Laboratory animal models provide important data on the dynamics of bacterial infection inside a living organism, but observations are limited. Using mathematical models, my aim is to extract as much information as possible from experimental data to make inference about the unobserved processes that drive the spatiotemporal dynamics of bacteria. In particular, I try to assess variations in the replication and death rates of bacteria, and their spread within and among tissues.
Team members: Myrto Vlazaki.
My work covers several bacterial pathogens thanks to a fantastic network of collaborators:
- Salmonella enterica, with Andrew Grant and Piero Mastroeni (in this Department), Dirk Bumann (Basel University), Emma Slack and Wolf Hardt (ETH Zurich).
- Bordetella bronchiseptica, with Eric Harvill (University of Georgia) and Monica Cartelle Gestal (Louisiana State University).
- Optimal experimental design, with David Price (University of Melbourne)
Funding: BBSRC, MRC.
2. Quantitative tools for multi-drug resistance in farm animals
Antimicrobial resistance (AMR) is a major threat to human and animal health. Multi-drug resistance is a particular concern, and is increasingly reported using genetic (sequencing) or phenotypic (growth inhibition assay) tools. However, analysing and interpreting these complex datasets requires sophisticated and ofter tailor-made computational techniques. We are investigating the epidemiology and evolution of multi-drug resistance in pathogenic, commensal and zoonotic bacterial pathogens in farm animals.
Team members: Andrew Balmer.
Collaborators: Mark Holmes, Lucy Weinert (Cambridge), Jose Vazquez-Boland (Edinburgh).
3. Wildlife and zoonotic disease ecology.
The emergence of new viruses from bats in the last 30 years has drawn the attention of a broad scientific community to the ecology and immunology of this diverse group of mammals. We have established a successful international collaboration centred in Ghana to study African fruit bats, their ecology, their viruses and their interactions with people.
Team members: Aaron Morris, Elinor Jax, Emma Glennon, Rakesh Chand.
Collaborators:
- Richard Suu Ire, Osbourne Quaye and Kofi Bonney (University of Ghana)
- Andrew Cunningham (Institute of Zoology, ZSL)
- Raina Plowright (Montana State University)
- Hamish McCallum and Alison Peel (Griffith University)
Funding: NSF, The Royal Society, AXA Foundation, DARPA.
Recent Publications
- Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections. M Vlazaki, J Huber, O Restif (2019) Pathogens and Disease 77 (8), ftaa001
- Estimating undetected Ebola spillovers EE Glennon, FL Jephcott, O Restif, JLN Wood (2019) PLOS Neglected Tropical Diseases 13 (6), e0007428
- What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts EE Glennon et al (2019) Philosophical Transactions of the Royal Society B 374 (1782), 20190021.
- Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir–Host Populations RK Plowright, AJ Peel, DG Streicker, AT Gilbert, H McCallum, J Wood, M Baker and O Restif (2016) PLOS Negl Trop Dis 10 (8), e0004796
- The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo. Coward C, Restif O et al. (2014) PLoS Pathogens, 10(9): e1004359.
- The effect of seasonal birth pulses on pathogen persistence in wild mammal populations. AJ Peel, JRC Pulliam, AD Luis, RK Plowright, TJ O'Shea, DTS Hayman, JLN Wood, CT Webb, O Restif (2014) Proc R Soc B, 281:20132962.
- Model‐guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics. Restif O et al. (2012) Ecology Letters 15:1083.
