Pathogenesis and immunobiology of bacterial infections
My current research develops and applies multidisciplinary approaches to unravel the links between in vivo pathogen behaviour (location, division, death, gene regulation and spread), immunity, immunoevasion and the efficacy of vaccines and antibiotics. We are currently extending our research to clinical setting to understand immunological risk factors that increase susceptibility to invasive bacterial infections; this will support the development and evaluation of vaccines for African children.
Key Publications
Immunological basis of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia. T. Nyirenda, W. Mandala, M. Gordon, Pietro Mastroeni. Microbes and Infection, in press
Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment. O. Rossi, R. Dybowski, D. Maskell, A. Grant, O. Restif, P. Mastroeni. J. Antimicrob. Chemother., https://doi.org/10.1093/jac/dkx294.
Transcriptome and proteome analysis of Salmonella enterica Serovar Typhimurium Infection of wild type C57BL/6 and immunodeficient gp91-/-phoxmice. O. Oshota, M. Fookes, F. Schreiber, R.Chaudhuri, L. Yu, F. Morgan, S. Clare, J. Choudhary, N. Thomson, D. Maskell, Pietro Mastroeni, A. Grant. Plos One., 2017 Aug 10;12(8):e0181365. doi: 10.1371/journal.pone.0181365
Genes required for the fitness of Salmonella enterica serovar Typhimurium during infection of immunodeficient gp91-/-phox mice". A. Grant, O. Oshota, R. Chaudhuri, M. Mayho, S. Peters, S. Clare, D. Maskell, Pietro Mastroeni. Infect. Immun. 2016; pii: IAI.01423-15.
Immunology, epidemiology and mathematical modelling towards a better understanding of invasive non-typhoidal Salmonella disease and rational vaccination approaches. Pietro Mastroeni, O. Rossi. Expert Reviews of Vaccines, 2016, DOI:10.1080/14760584.2016.1189330.
Design of glycoconjugate vaccines against invasive African S. Typhimurium. S. Rondini, F. Micoli, L. Lanzilao, M. Gavini, Pietro Mastroeni, C. Brandt, A. Saul, C. MacLennan. Infect. Immun. 2015; 83:996-1007.
The effects of vaccination and immunity on bacterial infection dynamics in vivo. C. Coward, O. Restif, R. Dybowski, A. Grant, D. Maskell, Pietro Mastroeni. PLoS Pathog. 2014; 10(9):e1004359
Quantification of the effects of antibodies on the extra- and intracellular dynamics of Salmonella enterica. O. Restif, Y. Goh, M. Palayret, A. Grant, T. McKinley, J. Gog, Pietro Mastroeni. J. R. Soc. Interface. 2013; 10: 20120866
Attenuated Salmonella Typhimurium lacking the pathogenicity island-2 type 3 secretion system grow to high bacterial numbers inside phagocytes in mice. A. Grant, F. Morgan, T. McKinley, G. Foster, D. Maskell, Pietro Mastroeni. PLoS Pathog. 2012; 8: e1003070